Vélez Sarsfield beat Newell's Old Boys 1-0. The winner had to work for it: 1 from 13 shots. Newell's Old Boys played with ten from minute 57. Best on the pitch was T. Guidara, rated 7.9.

1. 0'
   ⚽Kick-off
   Copa de la Liga Profesional 2021
   ARG 4-2-3-1·4-2-3-1 ARG
   Coach: M. Pellegrino · F. KudelkaReferee: P. Loustau📍 Estadio José Amalfitani
2. 1. First half
   2. 23'
      ARG
      Yellow card
      Pablo Pérez
   3. 26'
      ARG
      Substitution
      ▲L. Orellano▼A. Bouzat
   4. 35'
      ARG
      GOOOAL!J. LuceroAssist: F. Ortega
   5. 45'
      ARG
      Yellow card
      Federico Mancuello
3. 1. Second half
   2. 57'
      ARG
      Yellow card
      Pablo Pérez
   3. 57'
      ARG
      Red card
      Pablo Pérez
   4. 62'
      ARG
      Substitution
      ▲Julián Fernández▼J. Cacciabue
   5. 62'
      ARG
      Substitution
      ▲Maximiliano Rodríguez▼N. Castro
   6. 66'
      ARG
      Yellow card
      Julián Fernández
   7. 68'
      ARG
      Substitution
      ▲Cristian Tarragona▼R. Centurión
   8. 69'
      ARG
      Substitution
      ▲A. Mulet▼Federico Mancuello
   9. 71'
      ARG
      Substitution
      ▲Mauro Formica▼I. Scocco
   10. 71'
       ARG
       Substitution
       ▲Juan Sforza▼B. Rivero
   11. 80'
       ARG
       Substitution
       ▲A. Rodríguez▼J. Marcioni
   12. 85'
       ARG
       Substitution
       ▲H. De La Fuente▼T. Guidara
   13. 86'
       ARG
       Substitution
       ▲R. Álvarez▼J. Lucero