Defensa y Justicia beat Patronato 1-0. Best on the pitch was E. Unsain, rated 7.9.

1. 0'
   ⚽Kick-off
   Copa de la Liga Profesional 2021
   ARG 3-4-3·4-4-2 ARG
   Coach: S. Beccacece · I. DelfinoReferee: A. Merlos📍 Estadio Norberto Tito Tomaghello
2. 1. First half
   2. 16'
      ARG
      Yellow card
      F. Paredes
   3. 39'
      ARG
      Yellow card
      N. Breitenbruch
3. 1. Second half
   2. 48'
      ARG
      Yellow card
      A. Frías
   3. 58'
      ARG
      Substitution
      ▲M. Benítez▼V. Larralde
   4. 58'
      ARG
      Substitution
      ▲Emanuel Brítez▼F. Paredes
   5. 62'
      ARG
      Substitution
      ▲H. Canteros▼J. Arias
   6. 67'
      ARG
      Substitution
      ▲G. Hachen▼N. Breitenbruch
   7. 68'
      ARG
      Substitution
      ▲T. Martínez▼Walter Bou
   8. 71'
      ARG
      Substitution
      ▲Germán Rivero▼N. Bandiera
   9. 75'
      ARG
      GOOOAL!B. RomeroAssist: T. Martínez
   10. 79'
       ARG
       Substitution
       ▲M. Palavecino▼B. Nievas
   11. 79'
       ARG
       Substitution
       ▲L. Comas▼F. Leys
   12. 79'
       ARG
       Substitution
       ▲J. Barinaga▼F. Dettler
   13. 80'
       ARG
       Yellow card
       M. Benítez
   14. 81'
       ARG
       Yellow card
       D. Gissi
   15. 90+1'
       ARG
       Substitution
       ▲J. Rodriguez▼G. Hachen