Independiente beat Newell's Old Boys 1-2. Newell's Old Boys controlled the ball — 66% possession — but had nothing to show for it. Best on the pitch was Maximiliano Rodríguez, rated 8.0.

1. 0'
   ⚽Kick-off
   Copa de la Liga Profesional 2021
   ARG 4-2-3-1·5-3-2 ARG
   Coach: F. Kudelka · J. FalcioniReferee: P. Echavarría📍 Estadio Marcelo Alberto Bielsa
2. 1. First half
   2. 9'
      ARG
      GOOOAL!S. PalaciosAssist: S. Romero
   3. 16'
      ARG
      Yellow card
      Fabricio Bustos
   4. 32'
      ARG
      Yellow card
      Pablo Pérez
   5. 32'
      ARG
      GOOOAL!Fabricio BustosAssist: J. Menéndez
3. 1. Second half
   2. 46'
      ARG
      Substitution
      ▲J. Cristaldo▼A. Rodríguez
   3. 54'
      ARG
      Yellow card
      Agustín Franco
   4. 55'
      ARG
      Yellow card
      I. Scocco
   5. 59'
      ARG
      Substitution
      ▲L. Cingolani▼J. Marcioni
   6. 63'
      ARG
      Substitution
      ▲L. Romero▼L. Gonzalez
   7. 73'
      ARG
      Substitution
      ▲F. Negri▼M. Orihuela
   8. 73'
      ARG
      Substitution
      ▲Fernando Belluschi▼Pablo Pérez
   9. 75'
      ARG
      GOOOAL!Maximiliano RodríguezAssist: M. Llano
   10. 80'
       ARG
       Yellow card
       M. Capasso
   11. 80'
       ARG
       Substitution
       ▲Andrés Roa▼J. Menendez
   12. 80'
       ARG
       Substitution
       ▲A. Arregui▼D. Blanco
   13. 85'
       ARG
       Yellow card
       Maximiliano Rodríguez
   14. 89'
       ARG
       Substitution
       ▲L. Rodriguez▼G. Togni
   15. 89'
       ARG
       Substitution
       ▲N. Messiniti▼S. Romero
   16. 90+5'
       ARG
       Yellow card
       S. Sosa