Gimnasia de La Plata and Defensa y Justicia drew 1-1. Defensa y Justicia played with ten from minute 85. Best on the pitch was E. Isnaldo, rated 8.2.

1. 0'
   ⚽Kick-off
   Copa de la Liga Profesional 2021
   ARG 4-4-2·4-4-2 ARG
   Coach: M. Messera · S. BeccaceceReferee: N. Pitana📍 Estadio Juan Carmelo Zerillo
2. 1. First half
   2. 27'
      ARG
      Yellow card
      A. Frías
   3. 30'
      ARG
      Yellow card
      M. Weigandt
   4. 33'
      ARG
      Yellow card
      F. Meza
   5. 37'
      ARG
      Yellow card
      Enzo Fernández
3. 1. Second half
   2. 46'
      ARG
      Substitution
      ▲T. Martínez▼L. T. Escalante
   3. 48'
      ARG
      GOOOAL!J. CarboneroAssist: B. Alemán
   4. 57'
      ARG
      Substitution
      ▲G. Hachen▼Walter Bou
   5. 70'
      ARG
      GOOOAL!E. IsnaldoAssist: F. Pizzini
   6. 71'
      ARG
      Substitution
      ▲E. Ramirez▼M. Miranda
   7. 73'
      ARG
      Yellow card
      Emanuel Brítez
   8. 74'
      ARG
      Substitution
      ▲L. Contín▼Lucas Barrios
   9. 75'
      ARG
      Yellow card
      M. Benítez
   10. 82'
       ARG
       Yellow card
       E. Ramirez
   11. 82'
       ARG
       Substitution
       ▲C. Rotondi▼E. Isnaldo
   12. 85'
       ARG
       Yellow card
       F. Meza
   13. 85'
       ARG
       Red card
       F. Meza
   14. 86'
       ARG
       Substitution
       ▲J. Rodriguez▼F. Pizzini