Unión beat Patronato 0-1. Best on the pitch was H. Canteros, rated 7.7.

1. 0'
   ⚽Kick-off
   Copa de la Liga Profesional 2021
   ARG 5-3-2·5-4-1 ARG
   Coach: I. Delfino · J. AzconzábalReferee: F. Espinoza📍 Estadio Presbítero Bartolomé Grella
2. 1. Second half
   2. 46'
      ARG
      Substitution
      ▲M. Borgnino▼G. Gonzalez
   3. 54'
      ARG
      Yellow card
      N. Peñailillo
   4. 60'
      ARG
      Yellow card
      J. Garcia
   5. 64'
      ARG
      GOOOAL!J. Garcia
   6. 65'
      ARG
      Substitution
      ▲M. Palavecino▼D. Gissi
   7. 65'
      ARG
      Substitution
      ▲N. Delgadillo▼J. Barinaga
   8. 65'
      ARG
      Substitution
      ▲I. Machuca▼K. Zenon
   9. 65'
      ARG
      Substitution
      ▲C. Corvalan▼N. Peñailillo
   10. 71'
       ARG
       Substitution
       ▲N. Franco▼N. Bandiera
   11. 71'
       ARG
       Substitution
       ▲F. Márquez▼J. Garcia
   12. 80'
       ARG
       Substitution
       ▲A. Pastorelli▼H. Canteros
   13. 88'
       ARG
       Yellow card
       A. Pastorelli
   14. 90+4'
       ARG
       Substitution
       ▲B. Blasi▼F. Vera