Defensa y Justicia beat Newell's Old Boys 4-0. M. Benítez scored 2 goals. Best on the pitch was M. Benítez, rated 9.2.

1. 0'
   ⚽Kick-off
   Copa de la Liga Profesional 2021
   ARG 4-4-2·4-2-3-1 ARG
   Coach: S. Beccacece · F. KudelkaReferee: F. Rapallini📍 Estadio Norberto Tito Tomaghello
2. 1. First half
   2. 3'
      ARG
      Yellow card
      Emanuel Brítez
   3. 7'
      ARG
      GOOOAL!M. Benítez
   4. 26'
      ARG
      GOOOAL!M. BenítezAssist: F. Pizzini
   5. 35'
      ARG
      Yellow card
      Julián Fernández
3. 1. Second half
   2. 46'
      ARG
      Substitution
      ▲Pablo Pérez▼R. Sordo
   3. 50'
      ARG
      GOOOAL!Walter BouPenalty
   4. 65'
      ARG
      Substitution
      ▲Fernando Belluschi▼Julián Fernández
   5. 66'
      ARG
      Substitution
      ▲J. Cristaldo▼Justo Giani
   6. 66'
      ARG
      Substitution
      ▲Juan Sforza▼J. Cacciabue
   7. 66'
      ARG
      GOOOAL!F. PizziniAssist: W. Bou
   8. 68'
      ARG
      Substitution
      ▲V. Larralde▼R. Loaiza
   9. 68'
      ARG
      Substitution
      ▲C. Rius▼T. Martínez
   10. 70'
       ARG
       Yellow card
       Juan Sforza
   11. 74'
       ARG
       Yellow card
       C. Lema
   12. 78'
       ARG
       Substitution
       ▲Miguel Merentiel▼Walter Bou
   13. 78'
       ARG
       Substitution
       ▲M. Llano▼Maximiliano Rodríguez
   14. 82'
       ARG
       Substitution
       ▲F. Paredes▼Emanuel Brítez
   15. 82'
       ARG
       Substitution
       ▲G. Hachen▼F. Pizzini