Colón beat Estudiantes de La Plata 0-2. Estudiantes de La Plata controlled the ball — 58% possession — but had nothing to show for it. Estudiantes de La Plata played with ten from minute 85. Luis Rodríguez scored 2 goals. Best on the pitch was Luis Rodríguez, rated 8.7.

1. 0'
   ⚽Kick-off
   Copa de la Liga Profesional 2021
   ARG 4-4-2·3-5-2 ARG
   Coach: R. Zielinski · E. DomínguezReferee: A. Penel📍 Estadio Jorge Luis Hirschi
2. 1. First half
   2. 28'
      ARG
      Yellow card
      I. Gomez
   3. 45'
      ARG
      Yellow card
      Á. Gonzalez
   4. 45+2'
      ARG
      GOOOAL!Luis Rodríguez
3. 1. Second half
   2. 46'
      ARG
      Substitution
      ▲D. Ayala▼I. Gomez
   3. 47'
      ARG
      Yellow card
      F. Lértora
   4. 59'
      ARG
      Substitution
      ▲Maximiliano Díaz▼Nicolas Pasquini
   5. 60'
      ARG
      Substitution
      ▲M. Castro▼Á. Gonzalez
   6. 60'
      ARG
      Substitution
      ▲P. Sabbag▼M. Cauteruccio
   7. 61'
      ARG
      Yellow card
      M. Castro
   8. 68'
      ARG
      Yellow card
      J. Sánchez Miño
   9. 76'
      ARG
      Substitution
      ▲S. Pierotti▼N. Leguizamón
   10. 81'
       ARG
       GOOOAL!Luis RodríguezAssist: E. Meza
   11. 84'
       ARG
       Substitution
       ▲Y. Góez▼A. Castro
   12. 85'
       ARG
       Red card
       Maximiliano Díaz
   13. 87'
       ARG
       Substitution
       ▲T. Sandoval▼Luis Rodríguez
   14. 90+4'
       ARG
       Yellow card
       Eric Meza