Central Córdoba (Santiago del Estero) and Estudiantes de La Plata drew 1-1.

1. 0'
   ⚽Kick-off
   Copa de la Liga Profesional 2021
   Coach: G. Coleoni · R. ZielinskiReferee: F. Tello📍 Estadio Alfredo Terrera
2. 1. First half
   2. 18'
      ARG
      GOOOAL!L. Brochero
   3. 23'
      ARG
      GOOOAL!L. Godoy
   4. 36'
      ARG
      Yellow card
      F. Noguera
3. 1. Second half
   2. 46'
      ARG
      Substitution
      ▲D. Sarmiento▼M. Cauteruccio
   3. 72'
      ARG
      Substitution
      ▲P. Argañaraz▼L. Sequeira
   4. 72'
      ARG
      Substitution
      ▲N. Barrios▼L. Brochero
   5. 76'
      ARG
      Substitution
      ▲M. Castro▼D. Ayala
   6. 76'
      ARG
      Substitution
      ▲Esteban Fernando González▼Á. Gonzalez
   7. 79'
      ARG
      Yellow card
      J. Rodriguez
   8. 82'
      ARG
      Substitution
      ▲N. Banegas▼O. Salomon
   9. 87'
      ARG
      Substitution
      ▲M. Montenegro▼C. Vega
   10. 87'
       ARG
       Substitution
       ▲J. Apaolaza▼Leandro Díaz
   11. 90+5'
       ARG
       Yellow card
       M. Montenegro