Colón and Rosario Central drew 0-0. Best on the pitch was P. Goltz, rated 7.9.

1. 0'
   ⚽Kick-off
   Copa de la Liga Profesional 2021
   ARG 3-5-2·3-4-1-2 ARG
   Coach: E. Domínguez · C. GonzálezReferee: F. Espinoza📍 Estadio Brigadier General Estanislao López
2. 1. First half
   2. 1'
      ARG
      Yellow card
      D. Martinez
   3. 35'
      ARG
      Yellow card
      R. Villagra
   4. 41'
      ARG
      Yellow card
      C. Ferreira
   5. 44'
      ARG
      Yellow card
      J. Broun
3. 1. Second half
   2. 65'
      ARG
      Yellow card
      L. Blanco
   3. 67'
      ARG
      Substitution
      ▲Facundo Farías▼C. Ferreira
   4. 70'
      ARG
      Substitution
      ▲A. Marinelli▼P. Cucchi
   5. 75'
      ARG
      Substitution
      ▲F. Torrent▼D. Martinez
   6. 76'
      ARG
      Yellow card
      Facundo Farías
   7. 83'
      ARG
      Yellow card
      R. Sangiovani
   8. 90+2'
      ARG
      Substitution
      ▲L. Gamba▼E. Vecchio