Rosario Central and Central Córdoba (Santiago del Estero) drew 2-2.

1. 0'
   ⚽Kick-off
   Copa de la Liga Profesional 2021
   Coach: C. González · G. ColeoniReferee: P. Echavarría📍 Estadio Dr. Lisandro de la Torre
2. 1. First half
   2. 8'
      ARG
      Yellow card
      D. Martinez
   3. 27'
      ARG
      Yellow card
      O. Salomon
   4. 45'
      ARG
      GOOOAL!Marco RubenPenalty
3. 1. Second half
   2. 47'
      ARG
      Yellow card
      G. Bettini
   3. 52'
      ARG
      GOOOAL!L. SequeiraAssist: M. Giménez
   4. 63'
      ARG
      GOOOAL!D. Martinez
   5. 73'
      ARG
      Substitution
      ▲C. Lattanzio▼J. Bay
   6. 73'
      ARG
      Substitution
      ▲P. Argañaraz▼L. Brochero
   7. 80'
      ARG
      Substitution
      ▲F. Torrent▼D. Martinez
   8. 81'
      ARG
      Yellow card
      A. Marinelli
   9. 83'
      ARG
      Substitution
      ▲H. Lopez▼J. Galeano
   10. 83'
       ARG
       Substitution
       ▲J. González▼G. Bettini
   11. 84'
       ARG
       Yellow card
       R. Sangiovani
   12. 86'
       ARG
       Yellow card
       G. Avila
   13. 86'
       ARG
       Substitution
       ▲P. Cucchi▼Marco Ruben
   14. 87'
       ARG
       Substitution
       ▲M. Rabuñal▼R. Sangiovani
   15. 90+6'
       ARG
       GOOOAL!M. Gimenez