Colón and Argentinos Juniors drew 0-0. Best on the pitch was L. Burián, rated 7.6.

1. 0'
   ⚽Kick-off
   Copa de la Liga Profesional 2021
   ARG 3-4-1-2·3-4-1-2 ARG
   Coach: E. Domínguez · G. MilitoReferee: A. Merlos📍 Estadio Brigadier General Estanislao López
2. 1. First half
   2. 32'
      ARG
      Substitution
      ▲C. Bernardi▼F. Lértora
   3. 33'
      ARG
      Yellow card
      F. Garcés
   4. 38'
      ARG
      Yellow card
      R. Aliendro
   5. 41'
      ARG
      Yellow card
      L. Ambrogio
3. 1. Second half
   2. 58'
      ARG
      Substitution
      ▲D. Sosa▼L. Ambrogio
   3. 65'
      ARG
      Substitution
      ▲W. Morelo▼Facundo Farías
   4. 65'
      ARG
      Substitution
      ▲S. Pierotti▼A. Castro
   5. 67'
      ARG
      Substitution
      ▲J. Pucheta▼M. Coronel
   6. 67'
      ARG
      Substitution
      ▲G. Florentin▼G. Carabajal
   7. 68'
      ARG
      Yellow card
      Lucas Villalba
   8. 71'
      ARG
      Yellow card
      G. Escobar
   9. 82'
      ARG
      Substitution
      ▲Y. Góez▼R. Aliendro
   10. 83'
       ARG
       Substitution
       ▲M. Pisano▼J. Gomez
   11. 83'
       ARG
       Substitution
       ▲F. Mater▼J. Cabrera
   12. 89'
       ARG
       Yellow card
       C. Bernardi
   13. 90+3'
       ARG
       Yellow card
       F. Mater