Newell's Old Boys beat Lanús 1-3. Lanús controlled the ball — 61% possession — but had nothing to show for it. Lanús played with ten from minute 66. J. Cacciabue scored 2 goals. Best on the pitch was J. Cacciabue, rated 9.2.

1. 0'
   ⚽Kick-off
   Copa de la Liga Profesional 2021
   ARG 4-1-4-1·3-4-3 ARG
   Coach: L. Zubeldía · G. BurgosReferee: D. Abal📍 Estadio Ciudad de Lanús - Néstor Díaz Pérez
2. 1. First half
   2. 9'
      ARG
      Yellow card
      Y. Cabral
   3. 14'
      ARG
      Yellow card
      P. De la Vega
   4. 21'
      ARG
      GOOOAL!J. SandAssist: F. Orozco
   5. 45'
      ARG
      GOOOAL!J. Cristaldo
3. 1. Second half
   2. 56'
      ARG
      Yellow card
      L. Morales
   3. 56'
      ARG
      Substitution
      ▲A. Bernabei▼P. De la Vega
   4. 56'
      ARG
      Substitution
      ▲N. Orsini▼F. Orozco
   5. 61'
      ARG
      GOOOAL!J. Cacciabue
   6. 65'
      ARG
      Yellow card
      T. Belmonte
   7. 65'
      ARG
      Yellow card
      J. Cristaldo
   8. 66'
      ARG
      Yellow card
      T. Belmonte
   9. 66'
      ARG
      Red card
      T. Belmonte
   10. 67'
       ARG
       Yellow card
       J. Sand
   11. 70'
       ARG
       Substitution
       ▲D. Calcaterra▼A. Rodríguez
   12. 73'
       ARG
       GOOOAL!J. CacciabueAssist: J. Cristaldo
   13. 76'
       ARG
       Substitution
       ▲L. Vera▼J. Aude
   14. 79'
       ARG
       Substitution
       ▲E. Cabrera▼Maximiliano Rodríguez
   15. 79'
       ARG
       Substitution
       ▲J. Freytes▼F. Negri
   16. 85'
       ARG
       Yellow card
       M. Esquivel
   17. 87'
       ARG
       Substitution
       ▲M. Jaime▼J. Cristaldo
   18. 90+3'
       ARG
       Yellow card
       J. Freytes