Colón beat Arsenal de Sarandí 2-0. The winner had to work for it: 2 from 18 shots. Best on the pitch was B. Bianchi, rated 8.2.

1. 0'
   ⚽Kick-off
   Copa de la Liga Profesional 2021
   ARG 3-5-2·4-3-1-2 ARG
   Coach: E. Domínguez · S. RondinaReferee: N. Pitana📍 Estadio Brigadier General Estanislao López
2. 1. First half
   2. 14'
      ARG
      GOOOAL!B. BianchiAssist: L. Rodríguez
   3. 28'
      ARG
      Yellow card
      F. Lértora
   4. 45+1'
      ARG
      GOOOAL!Facundo Farías
3. 1. Second half
   2. 56'
      ARG
      Substitution
      ▲B. Báez▼F. Kruspzky
   3. 56'
      ARG
      Substitution
      ▲N. Miracco▼Bruno Sepúlveda
   4. 60'
      ARG
      Yellow card
      Facundo Farías
   5. 66'
      ARG
      Substitution
      ▲Y. Góez▼A. Castro
   6. 66'
      ARG
      Substitution
      ▲W. Morelo▼Facundo Farías
   7. 76'
      ARG
      Substitution
      ▲G. Muscia▼J. Andrada
   8. 76'
      ARG
      Substitution
      ▲D. Buceta▼B. Farioli
   9. 83'
      ARG
      Substitution
      ▲Juan C. Ferreyra▼F. Lértora
   10. 84'
       ARG
       Substitution
       ▲M. Belloso▼M. Rogoski
   11. 89'
       ARG
       Yellow card
       G. Muscia
   12. 90+5'
       ARG
       Yellow card
       Luis Rodríguez