San Lorenzo beat Godoy Cruz 1-0. The winner had to work for it: 1 from 19 shots. Best on the pitch was S. Torrico, rated 8.5.

1. 0'
   ⚽Kick-off
   Copa de la Liga Profesional 2021
   ARG 4-3-1-2·4-1-4-1 ARG
   Coach: D. Dabove · S. MéndezReferee: S. Trucco📍 Estadio Pedro Bidegaín
2. 1. First half
   2. 26'
      ARG
      GOOOAL!Óscar RomeroPenalty
   3. 41'
      ARG
      Yellow card
      V. Salazar
3. 1. Second half
   2. 46'
      ARG
      Substitution
      ▲M. Ramirez▼Wilder Cartagena
   3. 46'
      ARG
      Substitution
      ▲T. Badaloni▼C. Colmán
   4. 54'
      ARG
      Substitution
      ▲M. Herrera▼V. Salazar
   5. 59'
      ARG
      Substitution
      ▲A. Martegani▼J. Elias
   6. 64'
      ARG
      Yellow card
      M. Dos Santos
   7. 65'
      ARG
      Substitution
      ▲V. Burgoa▼S. Lomonaco
   8. 66'
      ARG
      Substitution
      ▲F. Henríquez▼Luciano Pizarro
   9. 76'
      ARG
      Yellow card
      G. Ferrari
   10. 83'
       ARG
       Substitution
       ▲B. Pitton▼J. Ramirez
   11. 83'
       ARG
       Substitution
       ▲M. Peralta▼N. Fernandez
   12. 84'
       ARG
       Yellow card
       S. Torrico