Independiente knocked Estudiantes de La Plata out on penalties 4-1, after a 0-0 draw. Independiente played with ten from minute 59.

1. 0'
   ⚽Kick-off
   Copa de la Liga Profesional 2021
   Coach: R. Zielinski · J. FalcioniReferee: P. Echavarría📍 Estadio Jorge Luis Hirschi
2. 1. First half
   2. 33'
      ARG
      Yellow card
      A. Rogel
3. 1. Second half
   2. 46'
      ARG
      Substitution
      ▲Esteban Fernando González▼Leandro Díaz
   3. 46'
      ARG
      Substitution
      ▲D. Ayala▼Nicolas Pasquini
   4. 50'
      ARG
      Yellow card
      T. Ortega
   5. 59'
      ARG
      Yellow card
      T. Ortega
   6. 59'
      ARG
      Red card
      T. Ortega
   7. 61'
      ARG
      Substitution
      ▲L. Rodriguez▼S. Palacios
   8. 75'
      ARG
      Yellow card
      J. Apaolaza
   9. 79'
      ARG
      Substitution
      ▲P. Sabbag▼Á. Gonzalez
   10. 82'
       ARG
       Substitution
       ▲B. Martinez▼A. Velasco
   11. 86'
       ARG
       Yellow card
       P. Sabbag
   12. 87'
       ARG
       Yellow card
       Juan M. Insaurralde
   13. 90+1'
       ARG
       Substitution
       ▲M. Castro▼L. Godoy
   14. 90+1'
       ARG
       Substitution
       ▲A. Arregui▼L. Gonzalez
4. 1. Penalties
   2. 120+1'
      ARG
      GOOOAL!S. RomeroPenalty shootout
   3. 120+2'
      ARG
      Shootout miss
      M. Cauteruccio
   4. 120+3'
      ARG
      GOOOAL!L. RodriguezPenalty shootout
   5. 120+4'
      ARG
      Shootout miss
      F. Noguera
   6. 120+5'
      ARG
      GOOOAL!D. BlancoPenalty shootout
   7. 120+6'
      ARG
      GOOOAL!L. RodríguezPenalty shootout
   8. 120+7'
      ARG
      GOOOAL!B. MartinezPenalty shootout