Colón beat Independiente 0-2. The winner had to work for it: 2 from 14 shots. Best on the pitch was F. Lértora, rated 7.7.

1. 0'
   ⚽Kick-off
   Copa de la Liga Profesional 2021
   ARG 4-3-3·4-3-1-2 ARG
   Coach: J. Falcioni · E. DomínguezReferee: D. Abal📍 Estadio San Juan del Bicentenario
2. 1. First half
   2. 21'
      ARG
      GOOOAL!Luis RodríguezPenalty
   3. 23'
      ARG
      Yellow card
      Juan M. Insaurralde
   4. 25'
      ARG
      Yellow card
      S. Palacios
   5. 38'
      ARG
      Yellow card
      R. Delgado
   6. 45'
      ARG
      Yellow card
      Luis Rodríguez
   7. 45+1'
      ARG
      Yellow card
      L. Romero
3. 1. Second half
   2. 54'
      ARG
      Yellow card
      S. Barreto
   3. 62'
      ARG
      Yellow card
      D. Blanco
   4. 63'
      ARG
      Substitution
      ▲A. Velasco▼S. Palacios
   5. 65'
      ARG
      Substitution
      ▲S. Pierotti▼Christian Bernardi
   6. 67'
      ARG
      GOOOAL!S. PierottiAssist: A. Castro
   7. 70'
      ARG
      Substitution
      ▲J. Herrera▼D. Blanco
   8. 79'
      ARG
      Substitution
      ▲Juan C. Ferreyra▼S. Pierotti
   9. 79'
      ARG
      Substitution
      ▲Y. Góez▼Facundo Farías
   10. 81'
       ARG
       Substitution
       ▲A. Soñora▼G. Asis
   11. 81'
       ARG
       Substitution
       ▲B. Martinez▼Andrés Roa
   12. 89'
       ARG
       Substitution
       ▲L. Acevedo▼A. Castro