Newell's Old Boys beat Defensa y Justicia 1-0. The winner had to work for it: 1 from 23 shots. Defensa y Justicia played with ten from minute 21. Best on the pitch was Leonel Vangioni, rated 8.0.

1. 0'
   ⚽Kick-off
   Copa de la Liga Profesional 2022
   ARG 4-2-3-1·4-4-1-1 ARG
   Coach: J. Sanguinetti · S. BeccaceceReferee: A. Merlos📍 Estadio Marcelo Alberto Bielsa
2. 1. First half
   2. 21'
      ARG
      Red card
      Nazareno Colombo
   3. 25'
      ARG
      Substitution
      ▲K. Gutierrez▼G. Hachen
   4. 40'
      ARG
      Yellow card
      Pablo Pérez
3. 1. Second half
   2. 51'
      ARG
      Yellow card
      F. Pizzini
   3. 59'
      ARG
      GOOOAL!F. GonzalezAssist: R. Sordo
   4. 64'
      ARG
      Substitution
      ▲J. Cacciabue▼Pablo Pérez
   5. 64'
      ARG
      Substitution
      ▲J. Garcia▼R. Sordo
   6. 67'
      ARG
      Substitution
      ▲Justo Giani▼F. Gonzalez
   7. 70'
      ARG
      Substitution
      ▲T. Galvan▼F. Pizzini
   8. 82'
      ARG
      Substitution
      ▲A. Fontana▼C. Rotondi
   9. 83'
      ARG
      Substitution
      ▲G. Balzi▼N. Castro