Newell's Old Boys beat Patronato 1-0. The winner had to work for it: 1 from 12 shots. Best on the pitch was R. Lozano, rated 7.3.

1. 0'
   ⚽Kick-off
   Copa de la Liga Profesional 2022
   ARG 4-1-4-1·4-4-2 ARG
   Coach: J. Sanguinetti · F. SavaReferee: N. Pitana📍 Estadio Marcelo Alberto Bielsa
2. 1. First half
   2. 22'
      ARG
      Yellow card
      F. Cobos
   3. 41'
      ARG
      Substitution
      ▲F. Herrera▼R. Macagno
   4. 44'
      ARG
      Substitution
      ▲L. Geminiani▼F. Cobos
   5. 45+2'
      ARG
      Yellow card
      M. Luciano
3. 1. Second half
   2. 46'
      ARG
      Substitution
      ▲R. Sordo▼F. Gonzalez
   3. 60'
      ARG
      Substitution
      ▲D. Reasco▼N. Castro
   4. 60'
      ARG
      Substitution
      ▲Juan Sforza▼Pablo Pérez
   5. 68'
      ARG
      Substitution
      ▲Justo Giani▼J. Garro
   6. 69'
      ARG
      Substitution
      ▲J. Herrera▼Lucas Barrios
   7. 70'
      ARG
      Yellow card
      Justo Giani
   8. 79'
      ARG
      GOOOAL!R. SordoAssist: D. Reasco
   9. 83'
      ARG
      Yellow card
      N. Castro
   10. 85'
       ARG
       Substitution
       ▲M. Ortiz▼G. Gudiño
   11. 85'
       ARG
       Substitution
       ▲S. Medina▼D. García
   12. 85'
       ARG
       Substitution
       ▲J. Valdez▼F. Leys
   13. 89'
       ARG
       Yellow card
       L. Geminiani