Colón and Independiente drew 2-2. Best on the pitch was Luis Rodríguez, rated 8.2.

1. 0'
   ⚽Kick-off
   Copa de la Liga Profesional 2022
   ARG 3-1-4-2·4-3-3 ARG
   Coach: J. Falcioni · E. DomínguezReferee: F. Espinoza📍 Estadio Brigadier General Estanislao López
2. 1. First half
   2. 23'
      ARG
      GOOOAL!L. BeltránAssist: L. Rodríguez
   3. 25'
      ARG
      Yellow card
      L. Beltrán
   4. 29'
      ARG
      GOOOAL!D. BlancoAssist: D. Batallini
   5. 35'
      ARG
      Yellow card
      T. A. Pozzo
3. 1. Second half
   2. 54'
      ARG
      GOOOAL!Luis Rodríguez
   3. 64'
      ARG
      Substitution
      ▲Andrés Roa▼C. Benavídez
   4. 64'
      ARG
      Substitution
      ▲L. Benegas▼Damián Batallini
   5. 65'
      ARG
      GOOOAL!L. BenegasAssist: J. Laso
   6. 67'
      ARG
      Substitution
      ▲J. Sandoval▼Eric Meza
   7. 75'
      ARG
      Substitution
      ▲S. Pierotti▼A. Teuten
   8. 75'
      ARG
      Substitution
      ▲B. Farioli▼Christian Bernardi
   9. 76'
      ARG
      Substitution
      ▲L. Rodriguez▼T. A. Pozzo
   10. 79'
       ARG
       Substitution
       ▲R. Abila▼L. Beltrán
   11. 79'
       ARG
       Substitution
       ▲Facundo Farías▼Luis Rodríguez
   12. 87'
       ARG
       Substitution
       ▲R. L. Marquez De Meneses▼G. Togni
   13. 90'
       ARG
       Yellow card
       S. Sosa