Newell's Old Boys beat Ituzaingó 3-1. Ituzaingó played with ten from minute 72.

1. 0'
   ⚽Kick-off
   Copa Argentina 2021
   Coach: J. Sanguinetti · M. De CiccoReferee: P. Giménez📍 Estadio Presbítero Bartolomé Grella
2. 1. First half
   2. 11'
      ARG
      GOOOAL!G. Rossi
   3. 30'
      ARG
      GOOOAL!J. Garro
   4. 34'
      ARG
      GOOOAL!A. Miranda
   5. 43'
      ARG
      GOOOAL!Juan Sforza
3. 1. Second half
   2. 46'
      ARG
      Substitution
      ▲H. Abal▼R. Soria
   3. 46'
      ARG
      Substitution
      ▲J. Arias▼A. Miranda
   4. 46'
      ARG
      Substitution
      ▲N. Lugli▼J. Maza
   5. 55'
      ARG
      Substitution
      ▲F. Gutiérrez▼F. Duré
   6. 60'
      ARG
      Substitution
      ▲B. Aguirre▼J. Garro
   7. 60'
      ARG
      Substitution
      ▲G. Balzi▼N. Castro
   8. 69'
      ARG
      Substitution
      ▲L. Nebot▼E. Mantovani
   9. 72'
      ARG
      Red card
      A. Rios
   10. 75'
       ARG
       Substitution
       ▲G. Velazquez▼W. Ditta
   11. 75'
       ARG
       Substitution
       ▲N. Funez▼G. Rossi
   12. 79'
       ARG
       Substitution
       ▲J. Cacciabue▼M. Portillo