Deportes Iquique beat Santa Fe 2-1. The winner had to work for it: 2 from 18 shots. Edson Puch scored 2 goals. Best on the pitch was Edson Puch, rated 8.2.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2025
   CHI 4-2-3-1·4-2-3-1 COL
   Coach: Fernando Maximiliano Díaz Seguel · Jorge Rodrigo BavaReferee: Perez Gutierrez, Roberto, Peru📍 Estadio Tierra de Campeones
2. 1. First half
   2. 2'
      COL
      GOOOAL!H. RodallegaAssist: H. Mosquera
   3. 17'
      COL
      Yellow card
      Kevin Andres Cuesta Rodriguez
   4. 22'
      COL
      Yellow card
      J. Angulo
   5. 35'
      CHI
      GOOOAL!Edson PuchAssist: C. Gonzalez
3. 1. Second half
   2. 46'
      COL
      Substitution
      ▲Christian Mafla▼J. Angulo
   3. 62'
      CHI
      Yellow card
      C. Fuentes
   4. 67'
      CHI
      VAR review
      Stefan Pino
   5. 70'
      COL
      Substitution
      ▲Edwar López▼H. Mosquera
   6. 70'
      CHI
      GOOOAL!Edson PuchPenalty
   7. 78'
      COL
      Substitution
      ▲L. Ríos▼O. Fernandez
   8. 79'
      COL
      Substitution
      ▲A. Rodríguez▼H. Rodallega
   9. 81'
      CHI
      Yellow card
      C. Gonzalez
   10. 87'
       CHI
       Substitution
       ▲M. Dávila▼E. Hoyos
   11. 87'
       CHI
       Substitution
       ▲B. Soto▼D. N. Fernandez C.
   12. 90+1'
       CHI
       Substitution
       ▲A. Ramos▼Edson Puch
   13. 90+1'
       COL
       Substitution
       ▲Y. A. Perlaza Perea▼A. Zapata