Santa Fe beat Deportes Iquique 2-1. The winner had to work for it: 2 from 31 shots. Best on the pitch was L. Requena, rated 9.3.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2025
   COL 4-1-4-1·4-3-3 CHI
   Coach: Jorge Rodrigo Bava · Fernando Maximiliano Díaz SeguelReferee: Derlis Lopez, Paraguay📍 Estadio Metropolitano de Techo
2. 1. First half
   2. 6'
      CHI
      GOOOAL!Stefan Pino
   3. 14'
      COL
      GOOOAL!E. Murillo
3. 1. Second half
   2. 46'
      COL
      Substitution
      ▲B. Soto▼D. N. Fernandez C.
   3. 46'
      CHI
      Substitution
      ▲Omar Albornoz▼Edwar López
   4. 60'
      CHI
      Substitution
      ▲A. Rodríguez▼O. Fernandez
   5. 60'
      CHI
      Substitution
      ▲H. Mosquera▼E. Murillo
   6. 63'
      COL
      Substitution
      ▲M. Dávila▼E. Hoyos
   7. 68'
      CHI
      Yellow card
      Stefan Pino
   8. 75'
      COL
      Substitution
      ▲A. Ramos▼Stefan Pino
   9. 76'
      CHI
      Substitution
      ▲Y. A. Perlaza Perea▼A. Zapata
   10. 76'
       CHI
       Substitution
       ▲L. Ríos▼Elvis Perlaza
   11. 87'
       COL
       Yellow card
       H. Rodallega
   12. 87'
       CHI
       Yellow card
       Edson Puch
   13. 90'
       COL
       GOOOAL!Christian MaflaAssist: L. Rios
   14. 90+1'
       COL
       Substitution
       ▲M. Blazquez▼C. Gonzalez