Club Nacional beat Atletico Nacional 1-0. Atletico Nacional controlled the ball — 61% possession — but had nothing to show for it. Best on the pitch was D. Asprilla, rated 7.7.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2025
   URU —·4-2-3-1 COL
   Coach: — · Diego Alejandro Arias HincapiéReferee: Nicolas Ramirez, Argentina📍 Gran Parque Central
2. 1. First half
   2. 3'
      URU
      Yellow card
      L. Boggio
   3. 31'
      URU
      Yellow card
      P. Calione
   4. 43'
      URU
      Yellow card
      L. Morales
3. 1. Second half
   2. 46'
      COL
      Yellow card
      J. Arias
   3. 66'
      URU
      Substitution
      ▲E. Mereles▼Rómulo Otero
   4. 67'
      URU
      Substitution
      ▲G. Petit▼Eduardo Vargas
   5. 74'
      URU
      Substitution
      ▲E. Ancheta▼L. Morales
   6. 77'
      COL
      Yellow card
      K. Viveros
   7. 77'
      COL
      Substitution
      ▲A. Sarmiento▼Billy Arce
   8. 82'
      COL
      Substitution
      ▲K. D. Toscano Bassa▼J. Zapata
   9. 82'
      COL
      Substitution
      ▲A. Morelos▼M. Hinestroza
   10. 88'
       URU
       GOOOAL!C. OlivaAssist: E. Ancheta
   11. 90'
       URU
       Substitution
       ▲B. Arady▼L. Boggio