Penarol and Vélez Sarsfield drew 0-0. Best on the pitch was Tomás Marchiori, rated 8.2.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2025
   URU —·4-2-3-1 ARG
   Coach: — · Guillermo Barros SchelottoReferee: Anderson Daronco, Brazil📍 Estadio Campeón del Siglo
2. 1. First half
   2. 27'
      URU
      Yellow card
      Léo Coelho
   3. 32'
      ARG
      Yellow card
      T. Galvan
   4. 45+2'
      ARG
      Yellow card
      A. Bouzat
3. 1. Second half
   2. 58'
      URU
      Substitution
      ▲D. García▼L. Umpierrez
   3. 73'
      URU
      Substitution
      ▲Lucas Hernández▼Maximiliano Olivera
   4. 73'
      URU
      Substitution
      ▲Héctor Villalba▼I. Sosa
   5. 79'
      ARG
      Substitution
      ▲L. Roldan▼C. Baeza
   6. 80'
      ARG
      Substitution
      ▲R. Cabral▼T. Galvan
   7. 83'
      URU
      Substitution
      ▲F. Avenatti▼M. Silvera
   8. 83'
      URU
      Substitution
      ▲D. Terans▼D. Suárez
   9. 90'
      ARG
      Substitution
      ▲M. Fernandez▼F. Pizzini