Club Nacional knocked Independiente del Valle out on penalties 4-2, after a 0-0 draw. Independiente del Valle controlled the ball — 77% possession — but had nothing to show for it. Best on the pitch was S. Rochet, rated 8.3.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2020
   URU 4-4-2·4-1-4-1 ECU
   Coach: J. Giordano · Miguel Ángel RamírezReferee: J. Benítez📍 Estadio Gran Parque Central
2. 1. First half
   2. 45'
      ECU
      Yellow card
      C. Ortiz
3. 1. Second half
   2. 58'
      URU
      Substitution
      ▲?▼Ignacio Lores
   3. 63'
      ECU
      Substitution
      ▲?▼J. Sánchez
   4. 77'
      URU
      Substitution
      ▲Rafael García▼C. Yacob
   5. 79'
      ECU
      Yellow card
      M. Ramirez
   6. 83'
      ECU
      Substitution
      ▲A. Landázuri▼Jacob Murillo
   7. 84'
      URU
      Substitution
      ▲A. Mendez▼Chori Castro
   8. 85'
      URU
      Yellow card
      A. Trezza
   9. 90+1'
      ECU
      Yellow card
      L. Faravelli
   10. 90+4'
       ECU
       Substitution
       ▲L. Faravelli▼E. Mera