Club Guarani and Royal Pari drew 1-1. Best on the pitch was Á. Benítez, rated 7.6.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   PAR 4-4-2·5-3-2 BOL
   Coach: G. Costas · C. DíazReferee: Rafael Traci📍 Estadio Luís Alfonso Giagni
2. 1. First half
   2. 20'
      PAR
      Yellow card
      J. Florentín
   3. 23'
      BOL
      Yellow card
      L. Ursino
   4. 33'
      PAR
      Yellow card
      Á. Benítez
3. 1. Second half
   2. 55'
      BOL
      Yellow card
      Rubilio Castillo
   3. 55'
      BOL
      Yellow card
      O. Siles
   4. 58'
      PAR
      GOOOAL!Á. Benítez
   5. 67'
      BOL
      Substitution
      ▲R. Cabrera▼O. Siles
   6. 67'
      BOL
      Substitution
      ▲Jefferson da Silva▼J. Amoroso
   7. 67'
      BOL
      Substitution
      ▲C. A. Melgar▼E. Orfano
   8. 69'
      PAR
      Substitution
      ▲F. Fernández▼R. Bobadilla
   9. 69'
      PAR
      Substitution
      ▲D. Villalva▼N. Maná
   10. 74'
       PAR
       Own goalJ. Florentín
   11. 75'
       PAR
       Substitution
       ▲J. Valdez▼A. Marín
   12. 75'
       PAR
       Substitution
       ▲J. Morel▼J. Florentín
   13. 82'
       PAR
       Yellow card
       Roberto Fernández
   14. 85'
       BOL
       Substitution
       ▲Jesus Manuel Sagredo Chavez▼Didi Torrico
   15. 90+1'
       PAR
       Substitution
       ▲N. Esteche▼J. Colmán