Santos beat Deportivo Lara 2-1. Best on the pitch was Kaiky, rated 8.3.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   BRA 4-2-3-1·5-4-1 VEN
   Coach: A. Holan · M. BrignaniReferee: A. Matonte📍 Estádio Urbano Caldeira
2. 1. First half
   2. 33'
      BRA
      Yellow card
      Alison
   3. 39'
      VEN
      Yellow card
      Ignacio Anzola
3. 1. Second half
   2. 50'
      BRA
      GOOOAL!Vinicius
   3. 52'
      VEN
      GOOOAL!Ignacio AnzolaAssist: L. Barrios
   4. 59'
      BRA
      Substitution
      ▲Gabriel Pirani▼Sandry
   5. 69'
      BRA
      Substitution
      ▲Jean Mota▼Marcos Leonardo
   6. 69'
      BRA
      GOOOAL!KaikyAssist: Jean Mota
   7. 70'
      VEN
      Substitution
      ▲J. Silva▼Luís Barrios
   8. 75'
      VEN
      Substitution
      ▲Á. Sánchez▼G. Salazar
   9. 75'
      VEN
      Substitution
      ▲J. Castillo▼T. Segovia
   10. 77'
       BRA
       Substitution
       ▲Bruninho▼Ângelo
   11. 80'
       VEN
       Yellow card
       Darwin Gomez
   12. 90+6'
       BRA
       Yellow card
       Vinicius
   13. 90+6'
       VEN
       Yellow card
       J. Castillo