Wanderers beat Bolívar 1-0. The winner had to work for it: 1 from 15 shots. Bolívar played with ten from minute 90. Best on the pitch was K. Rolón, rated 7.9.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   URU 3-4-1-2·4-2-3-1 BOL
   Coach: D. Carreño · Natxo GonzálezReferee: C. Garay📍 Parque Alfredo Víctor Viera
2. 1. First half
   2. 6'
      URU
      Yellow card
      Darwin Torres
   3. 10'
      BOL
      Substitution
      ▲J. García▼Álvaro Rey
3. 1. Second half
   2. 46'
      URU
      Substitution
      ▲D. Macaluso▼G. Alcoba
   3. 46'
      BOL
      Substitution
      ▲K. Salvatierra▼J. García
   4. 55'
      URU
      GOOOAL!K. Rolón
   5. 68'
      URU
      Substitution
      ▲D. Riolfo▼N. Quagliata
   6. 68'
      URU
      Substitution
      ▲D. Hernández▼K. Rolón
   7. 70'
      URU
      Yellow card
      César Araújo
   8. 71'
      URU
      Substitution
      ▲Maximiliano Perez▼M. Mendez
   9. 77'
      BOL
      Substitution
      ▲C. Menacho▼Bruno Miranda
   10. 79'
       BOL
       Yellow card
       L. Justiniano
   11. 82'
       URU
       Substitution
       ▲Santiago Martinez▼I. González
   12. 90'
       BOL
       Yellow card
       Alex Granell
   13. 90+6'
       BOL
       Red card
       Cesar Menacho