Universidad de Chile and San Lorenzo drew 1-1. Universidad de Chile controlled the ball — 63% possession — but had nothing to show for it. San Lorenzo played with ten from minute 62. Best on the pitch was J. Ramirez, rated 7.5.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   CHI 4-2-3-1·4-4-2 ARG
   Coach: R. Dudamel · D. DaboveReferee: Raphael Claus📍 Estadio Nacional Julio Martínez Prádanos
2. 1. First half
   2. 15'
      CHI
      Yellow card
      Mario Sandoval
   3. 17'
      ARG
      Yellow card
      G. Rojas
   4. 37'
      ARG
      Yellow card
      Julián Palacios
3. 1. Second half
   2. 59'
      ARG
      Substitution
      ▲Diego Manuel Rodríguez▼Y. Gordillo
   3. 62'
      ARG
      Red card
      D. Braghieri
   4. 64'
      ARG
      Substitution
      ▲F. Gattoni▼L. Melano
   5. 71'
      CHI
      Substitution
      ▲T. Rodriguez▼S. Contreras
   6. 71'
      CHI
      Substitution
      ▲N. Luján▼Joaquin Larrivey
   7. 72'
      CHI
      Yellow card
      Luis Casanova
   8. 76'
      CHI
      GOOOAL!Ángelo HenríquezAssist: M. Cañete
   9. 78'
      ARG
      GOOOAL!F. Di SantoAssist: F. Gattoni
   10. 79'
       ARG
       Substitution
       ▲Gino Peruzzi▼Julián Palacios
   11. 79'
       ARG
       Substitution
       ▲Angel Romero▼F. Di Santo
   12. 79'
       ARG
       Substitution
       ▲B. Pitton▼J. Ramirez
   13. 87'
       CHI
       Substitution
       ▲S. Galani▼Camilo Moya