Deportivo Lara and Santos drew 1-1. Santos controlled the ball — 66% possession — but had nothing to show for it. Best on the pitch was Ignacio Anzola, rated 7.9.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   VEN 5-3-2·4-2-3-1 BRA
   Coach: M. Brignani · A. HolanReferee: V. Carrillo📍 Estadio Olímpico de la UCV
2. 1. First half
   2. 29'
      VEN
      Substitution
      ▲G. Salazar▼Á. Sánchez
   3. 37'
      BRA
      GOOOAL!Yeferson Soteldo
3. 1. Second half
   2. 55'
      VEN
      Yellow card
      D. Meleán
   3. 57'
      VEN
      Yellow card
      Ignacio Anzola
   4. 61'
      VEN
      Substitution
      ▲B. Castillo▼Juan Castellanos
   5. 62'
      BRA
      Yellow card
      Jean Mota
   6. 62'
      VEN
      GOOOAL!Ignacio AnzolaAssist: C. Rodríguez
   7. 65'
      BRA
      Yellow card
      Sandry
   8. 66'
      BRA
      Substitution
      ▲Vinicius▼Jean Mota
   9. 76'
      BRA
      Substitution
      ▲Gabriel Pirani▼Sandry
   10. 76'
       BRA
       Substitution
       ▲Lucas Braga▼Ângelo
   11. 80'
       VEN
       Substitution
       ▲J. Castillo▼D. Meleán
   12. 82'
       BRA
       Substitution
       ▲Bruninho▼Marcos Leonardo