Gremio beat Ayacucho FC 1-2. The winner had to work for it: 2 from 12 shots. Best on the pitch was R. Ardiles, rated 8.2.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   PER 4-2-3-1·4-4-2 BRA
   Coach: W. Fiori · Renato GaúchoReferee: E. Ostojich📍 Estadio Olímpico Atahualpa
2. 1. First half
   2. 35'
      PER
      Yellow card
      E. Páucar
   3. 40'
      PER
      GOOOAL!L. SosaAssist: M. Quina
   4. 41'
      BRA
      GOOOAL!FerreiraAssist: Rodrigues
   5. 45+1'
      PER
      Yellow card
      R. Villamarín
3. 1. Second half
   2. 54'
      BRA
      Yellow card
      Ruan
   3. 62'
      BRA
      Substitution
      ▲Pedro Lucas▼Thaciano
   4. 63'
      BRA
      Substitution
      ▲Fernando Henrique▼Lucas Araujo
   5. 67'
      PER
      Substitution
      ▲C. Olascuaga▼L. Carranza
   6. 76'
      PER
      Yellow card
      Jesus Mendieta
   7. 78'
      BRA
      Substitution
      ▲Leonardo Chú▼Gui Azevedo
   8. 84'
      BRA
      Yellow card
      Fernando Henrique
   9. 87'
      BRA
      GOOOAL!Ricardinho
   10. 88'
       PER
       Substitution
       ▲J. Parodi▼Jesus Mendieta
   11. 88'
       PER
       Substitution
       ▲P. Casique▼R. Ardiles
   12. 88'
       BRA
       Substitution
       ▲Jhonata▼Darlan
   13. 88'
       BRA
       Substitution
       ▲Léo Pereira▼Ricardinho