San Lorenzo beat Universidad de Chile 2-0. The winner had to work for it: 2 from 15 shots. Best on the pitch was Angel Romero, rated 9.2.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   ARG 4-2-3-1·4-4-2 CHI
   Coach: D. Dabove · R. DudamelReferee: L. González📍 Estadio Pedro Bidegaín
2. 1. First half
   2. 13'
      ARG
      GOOOAL!F. Di SantoAssist: Á. Romero
   3. 24'
      CHI
      Yellow card
      Bastian Ubal
   4. 35'
      CHI
      Yellow card
      Ángelo Henríquez
   5. 45'
      CHI
      Yellow card
      Camilo Moya
3. 1. Second half
   2. 55'
      CHI
      Yellow card
      M. Morales
   3. 56'
      CHI
      Substitution
      ▲T. Rodriguez▼N. Luján
   4. 59'
      ARG
      GOOOAL!Angel RomeroAssist: J. Ramírez
   5. 63'
      CHI
      Yellow card
      T. Rodriguez
   6. 65'
      ARG
      Substitution
      ▲B. Pitton▼Angel Romero
   7. 67'
      ARG
      Yellow card
      F. Gattoni
   8. 74'
      ARG
      Yellow card
      D. Rodriguez
   9. 76'
      CHI
      Substitution
      ▲C. Muñoz▼Joaquin Larrivey
   10. 76'
       CHI
       Substitution
       ▲J. Castro▼M. Morales
   11. 78'
       ARG
       Substitution
       ▲S. Rosane▼Diego Manuel Rodríguez
   12. 78'
       ARG
       Substitution
       ▲N. Fernandez▼J. Ramirez
   13. 84'
       ARG
       Substitution
       ▲L. Melano▼F. Di Santo
   14. 84'
       ARG
       Substitution
       ▲F. Flores▼Julián Palacios
   15. 86'
       CHI
       Substitution
       ▲P. Aránguiz▼Camilo Moya
   16. 86'
       CHI
       Substitution
       ▲B. Cortés▼S. Contreras
   17. 89'
       CHI
       Yellow card
       Mauricio Morales