Atletico Nacional beat Club Guarani 3-0. Club Guarani played with ten from minute 47. A. Andrade scored 2 goals. Best on the pitch was A. Andrade, rated 8.3.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   COL 4-3-3·5-4-1 PAR
   Coach: A. Guimarães · G. CostasReferee: N. Pitana📍 Estadio Atanasio Girardot
2. 1. First half
   2. 4'
      COL
      Yellow card
      G. Perea
   3. 10'
      PAR
      Yellow card
      M. Benítez
   4. 24'
      COL
      GOOOAL!A. AndradeAssist: Y. Candelo
   5. 36'
      PAR
      Yellow card
      A. Marín
   6. 39'
      COL
      GOOOAL!J. Barrera
3. 1. Second half
   2. 46'
      PAR
      Substitution
      ▲Rodrigo Fernandez▼J. Morel
   3. 46'
      PAR
      Substitution
      ▲J. Colmán▼N. Maná
   4. 47'
      PAR
      Yellow card
      M. Benítez
   5. 47'
      PAR
      Red card
      M. Benítez
   6. 52'
      COL
      GOOOAL!A. AndradeAssist: J. Alvez
   7. 58'
      COL
      Substitution
      ▲E. Olivera▼G. Perea
   8. 58'
      COL
      Substitution
      ▲Vladimir Hernández▼S. Gomez
   9. 65'
      COL
      Substitution
      ▲Alex Castro▼J. Barrera
   10. 65'
       COL
       Substitution
       ▲J. Duque▼A. Andrade
   11. 68'
       PAR
       Substitution
       ▲F. Fernández▼R. Bobadilla
   12. 68'
       PAR
       Substitution
       ▲D. Villalva▼A. Marín
   13. 72'
       PAR
       Substitution
       ▲Á. Benítez▼J. Florentín
   14. 75'
       COL
       Yellow card
       Brayan Rovira
   15. 80'
       COL
       Substitution
       ▲M. Chacón▼Brayan Rovira
   16. 89'
       PAR
       Yellow card
       Guillermo Benítez