Santos beat San Lorenzo 1-3. Best on the pitch was Óscar Romero, rated 8.5.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   ARG 4-2-3-1·4-2-3-1 BRA
   Coach: D. Dabove · A. HolanReferee: W. Roldán📍 Estadio Pedro Bidegaín
2. 1. First half
   2. 7'
      BRA
      GOOOAL!Lucas BragaAssist: Luan Peres
   3. 31'
      ARG
      Substitution
      ▲Óscar Romero▼Julián Palacios
   4. 37'
      ARG
      Yellow card
      D. Rodriguez
   5. 45+1'
      BRA
      GOOOAL!MarinhoPenalty
3. 1. Second half
   2. 71'
      ARG
      Substitution
      ▲J. Elias▼Diego Manuel Rodríguez
   3. 71'
      ARG
      Substitution
      ▲N. Fernandez▼F. Troyansky
   4. 72'
      ARG
      GOOOAL!Angel RomeroAssist: Nicolás Emanuel Fernández
   5. 84'
      BRA
      Substitution
      ▲Ângelo▼Marinho
   6. 84'
      BRA
      Substitution
      ▲Yeferson Soteldo▼Gabriel Pirani
   7. 85'
      BRA
      Substitution
      ▲Bruninho▼Marcos Leonardo
   8. 90+3'
      BRA
      Substitution
      ▲Madson▼Lucas Braga
   9. 90+4'
      BRA
      GOOOAL!Ângelo