Libertad Asuncion beat Atletico Nacional 1-0. The winner had to work for it: 1 from 12 shots. Best on the pitch was C. Báez, rated 8.0.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   PAR 4-4-2·4-2-3-1 COL
   Coach: D. Garnero · A. GuimarãesReferee: F. Tello📍 Estadio Defensores del Chaco
2. 1. First half
   2. 45'
      PAR
      Yellow card
      Alex Terra
3. 1. Second half
   2. 58'
      PAR
      Substitution
      ▲Óscar Cardozo▼Adrián Martínez
   3. 60'
      COL
      Substitution
      ▲Vladimir Hernández▼M. Chacón
   4. 62'
      PAR
      Yellow card
      C. Báez
   5. 64'
      COL
      Yellow card
      Danovis Banguero
   6. 65'
      PAR
      Substitution
      ▲B. Cáceres▼R. Martínez
   7. 65'
      PAR
      Substitution
      ▲Héctor Villalba▼R. Bogarin
   8. 77'
      PAR
      Substitution
      ▲A. Oviedo▼S. Ferreira
   9. 77'
      PAR
      Substitution
      ▲P. Delvalle▼Ivan Franco
   10. 78'
       PAR
       GOOOAL!C. Báez
   11. 79'
       COL
       Substitution
       ▲J. Duque▼J. Alvez
   12. 79'
       COL
       Substitution
       ▲Alex Castro▼A. Andrade