Santos and San Lorenzo drew 2-2. San Lorenzo played with ten from minute 51. Best on the pitch was João Paulo, rated 8.6.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   BRA 4-2-3-1·4-1-4-1 ARG
   Coach: A. Holan · D. DaboveReferee: E. Ostojich📍 Estádio Nacional de Brasília
2. 1. First half
   2. 3'
      ARG
      Yellow card
      Gino Peruzzi
   3. 20'
      BRA
      Yellow card
      Alison
   4. 22'
      BRA
      Yellow card
      Marcos Leonardo
   5. 22'
      BRA
      GOOOAL!Marcos LeonardoAssist: Felipe Jonatan
   6. 24'
      ARG
      Yellow card
      F. Di Santo
   7. 45'
      BRA
      Yellow card
      João Paulo
3. 1. Second half
   2. 50'
      BRA
      Yellow card
      Luan Peres
   3. 51'
      ARG
      Red card
      G. Rojas
   4. 57'
      BRA
      GOOOAL!ParáAssist: Y. Soteldo
   5. 59'
      ARG
      GOOOAL!F. Di SantoAssist: Á. Romero
   6. 63'
      BRA
      Yellow card
      Marinho
   7. 64'
      ARG
      Yellow card
      Diego Manuel Rodríguez
   8. 67'
      BRA
      Substitution
      ▲Jean Mota▼Gabriel Pirani
   9. 67'
      BRA
      Substitution
      ▲Lucas Braga▼Marinho
   10. 78'
       ARG
       GOOOAL!Angel RomeroAssist: Ó. Romero
   11. 79'
       ARG
       Substitution
       ▲B. Pitton▼J. Ramirez
   12. 81'
       ARG
       Substitution
       ▲L. Melano▼N. Fernandez
   13. 81'
       ARG
       Substitution
       ▲J. Elias▼Diego Manuel Rodríguez
   14. 83'
       BRA
       Substitution
       ▲Jonathan Copete▼Yeferson Soteldo
   15. 90+1'
       BRA
       Substitution
       ▲Kaio Jorge▼Marcos Leonardo
   16. 90+1'
       BRA
       Substitution
       ▲Luiz Felipe▼Madson
   17. 90+1'
       ARG
       Substitution
       ▲F. Troyansky▼F. Di Santo