Atletico Nacional beat Libertad Asuncion 4-1. Best on the pitch was Y. Candelo, rated 7.6.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   COL 4-2-3-1·4-4-2 PAR
   Coach: A. Guimarães · D. GarneroReferee: R. Tobar📍 Estadio Atanasio Girardot
2. 1. First half
   2. -5'
      PAR
      Yellow card
      Alex Terra
   3. 2'
      PAR
      GOOOAL!Julio César EncisoAssist: H. Villalba
   4. 16'
      COL
      GOOOAL!J. Barrera
   5. 28'
      COL
      Yellow card
      A. Andrade
3. 1. Second half
   2. 46'
      COL
      Substitution
      ▲J. Duque▼S. Gomez
   3. 46'
      PAR
      Substitution
      ▲D. Viera▼Julio César Enciso
   4. 51'
      COL
      GOOOAL!B. PerlazaAssist: Y. Candelo
   5. 58'
      COL
      GOOOAL!J. Alvez
   6. 61'
      COL
      Substitution
      ▲G. Perea▼J. Alvez
   7. 65'
      PAR
      Substitution
      ▲P. Delvalle▼Ivan Franco
   8. 65'
      PAR
      Substitution
      ▲A. Oviedo▼Alex Terra
   9. 71'
      COL
      Substitution
      ▲Jonathan Marulanda▼J. Barrera
   10. 74'
       COL
       GOOOAL!J. DuqueAssist: A. Andrade
   11. 77'
       COL
       Yellow card
       A. Quintana
   12. 79'
       PAR
       Substitution
       ▲Adrián Martínez▼S. Ferreira
   13. 80'
       COL
       Substitution
       ▲Brayan Cordoba▼Y. Candelo
   14. 80'
       PAR
       Substitution
       ▲B. Cáceres▼R. Martínez
   15. 90+1'
       PAR
       Yellow card
       Daniel Bocanegra