Barcelona SC beat Santos 0-2. Santos controlled the ball — 66% possession — but had nothing to show for it. The winner had to work for it: 2 from 12 shots. Best on the pitch was Carlos Torres Garcés, rated 7.7.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   BRA 4-2-3-1·4-2-3-1 ECU
   Coach: A. Holan · F. BustosReferee: A. Matonte📍 Estádio Urbano Caldeira
2. 1. First half
   2. -5'
      ECU
      Yellow card
      Victor Mendoza
   3. 8'
      ECU
      Yellow card
      W. Riveros
   4. 27'
      ECU
      Yellow card
      E. Martínez
   5. 41'
      ECU
      Yellow card
      M. Pineida
3. 1. Second half
   2. 46'
      ECU
      Substitution
      ▲Sergio Lopez▼N. Molina
   3. 53'
      ECU
      GOOOAL!Carlos Torres GarcésAssist: L. Martínez
   4. 54'
      BRA
      Substitution
      ▲Lucas Braga▼Gabriel Pirani
   5. 56'
      BRA
      Substitution
      ▲Vinicius▼Madson
   6. 64'
      BRA
      Yellow card
      Yeferson Soteldo
   7. 69'
      BRA
      Own goalPará
   8. 71'
      ECU
      Substitution
      ▲Lupo Quiñónez▼M. Hoyos
   9. 81'
      BRA
      Substitution
      ▲Kaio Jorge▼Marcos Leonardo
   10. 81'
       BRA
       Substitution
       ▲Lucas Lourenço▼Alison
   11. 85'
       ECU
       Substitution
       ▲G. Mastriani▼Carlos Torres Garcés
   12. 85'
       ECU
       Substitution
       ▲J. Montaño▼E. Martínez
   13. 90+1'
       ECU
       Substitution
       ▲Matías Oyola▼D. Díaz