Boca Juniors beat The Strongest 0-1. The Strongest controlled the ball — 65% possession — but had nothing to show for it. Best on the pitch was L. Lopez, rated 7.7.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   BOL 4-3-3·4-4-2 ARG
   Coach: A. Illanes · M. RussoReferee: J. Ospina📍 Estadio Hernando Siles
2. 1. First half
   2. 7'
      ARG
      GOOOAL!S. VillaAssist: E. Almendra
   3. 33'
      BOL
      Yellow card
      D. Wayar
3. 1. Second half
   2. 55'
      ARG
      Substitution
      ▲L. Jara▼Agustín Almendra
   3. 60'
      BOL
      Yellow card
      R. Vaca
   4. 61'
      BOL
      Substitution
      ▲Rolando Blackburn▼J. Chura
   5. 64'
      ARG
      Substitution
      ▲Nicolás Capaldo▼C. Medina
   6. 74'
      BOL
      Substitution
      ▲Fran Pastor▼Fernando Marteli
   7. 75'
      BOL
      Yellow card
      G. Castillo
   8. 84'
      BOL
      Substitution
      ▲Jaime Arrascaita▼R. Castro
   9. 84'
      BOL
      Substitution
      ▲Rudy Cardozo▼R. Vaca
   10. 86'
       ARG
       Substitution
       ▲L. Vázquez▼S. Villa
   11. 86'
       ARG
       Substitution
       ▲Agustín Sández▼A. Obando
   12. 90+1'
       ARG
       Yellow card
       L. Vazquez