Cerro Porteno beat America de Cali 0-2. America de Cali controlled the ball — 68% possession — but had nothing to show for it. The winner had to work for it: 2 from 13 shots. Best on the pitch was Á. Cardozo Lucena, rated 7.7.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   COL 4-3-3·4-4-2 PAR
   Coach: J. Real · F. ArceReferee: F. Echenique📍 Estadio Alfonso López
2. 1. First half
   2. 29'
      PAR
      GOOOAL!R. MoralesAssist: E. Giménez
   3. 45'
      PAR
      Yellow card
      Á. Cardozo Lucena
3. 1. Second half
   2. 46'
      PAR
      Substitution
      ▲M. Boselli▼R. Morales
   3. 57'
      COL
      Substitution
      ▲A. Rodríguez▼L. Sánchez
   4. 70'
      COL
      Substitution
      ▲H. Quiñónes▼P. Ortiz
   5. 70'
      COL
      Substitution
      ▲G. Murillo▼L. Paz
   6. 77'
      COL
      Yellow card
      Y. Cabrera
   7. 82'
      PAR
      Substitution
      ▲Marco Cáceres▼Federico Carrizo
   8. 87'
      PAR
      Substitution
      ▲Mateus Gonçalves▼S. Arzamendia
   9. 87'
      PAR
      Substitution
      ▲A. Rodríguez▼C. Aquino
   10. 90'
       PAR
       GOOOAL!Á. Cardozo Lucena
   11. 90+2'
       COL
       Substitution
       ▲J. Malagón▼M. Torres
   12. 90+3'
       COL
       Yellow card
       C. Arrieta