Defensa y Justicia beat Universitario 3-0. Walter Bou scored 2 goals. Best on the pitch was Walter Bou, rated 9.0.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   ARG 3-4-2-1·4-2-3-1 PER
   Coach: S. Beccacece · Á. ComizzoReferee: A. Hermosilla📍 Estadio Norberto Tito Tomaghello
2. 1. First half
   2. 33'
      ARG
      GOOOAL!F. PizziniAssist: W. Bou
   3. 37'
      PER
      Substitution
      ▲A. Valera▼E. Gutiérrez
   4. 38'
      ARG
      Yellow card
      BPBeccacece S. (Not on pitch)
   5. 38'
      PER
      Yellow card
      Armando Alfageme
   6. 39'
      ARG
      Yellow card
      Emanuel Brítez
3. 1. Second half
   2. 54'
      ARG
      Yellow card
      F. Pizzini
   3. 58'
      PER
      Substitution
      ▲J. Murrugarra▼G. Barreto
   4. 65'
      ARG
      Yellow card
      A. Frías
   5. 66'
      PER
      Yellow card
      Hernan Novick
   6. 71'
      ARG
      GOOOAL!Walter BouAssist: N. Gallardo
   7. 75'
      PER
      Substitution
      ▲A. Osorio▼Hernan Novick
   8. 77'
      ARG
      Substitution
      ▲L. T. Escalante▼R. Loaiza
   9. 78'
      ARG
      Substitution
      ▲T. Martínez▼G. Hachen
   10. 80'
       ARG
       GOOOAL!Walter BouPenalty
   11. 87'
       ARG
       Substitution
       ▲C. Rius▼F. Pizzini
   12. 90+2'
       ARG
       Substitution
       ▲K. Lencina▼N. Gallardo
   13. 90+2'
       ARG
       Substitution
       ▲Miguel Merentiel▼Walter Bou