Cerro Porteno and Deportivo La Guaira drew 0-0. Cerro Porteno controlled the ball — 68% possession — but had nothing to show for it. Best on the pitch was C. Aquino, rated 8.2.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   PAR 4-4-2·5-3-2 VEN
   Coach: F. Arce · D. FaríasReferee: D. Herrera📍 Estadio General Pablo Rojas
2. 1. Second half
   2. 57'
      PAR
      Yellow card
      Mathias Villasanti
   3. 58'
      VEN
      Yellow card
      Diego Luna
   4. 60'
      PAR
      Yellow card
      J. Patiño
   5. 61'
      PAR
      Substitution
      ▲R. Morales▼Federico Carrizo
   6. 61'
      PAR
      Substitution
      ▲F. Ovelar▼E. Gimenez
   7. 69'
      PAR
      Substitution
      ▲S. Bareiro▼M. Boselli
   8. 73'
      VEN
      Substitution
      ▲J. Reyes▼D. González
   9. 73'
      VEN
      Substitution
      ▲Ronaldo Lucena▼Carlos Cermeño
   10. 80'
       VEN
       Substitution
       ▲Guillermo Marín▼F. Pol
   11. 86'
       VEN
       Substitution
       ▲Á. Peña▼A. Ocanto
   12. 89'
       PAR
       Substitution
       ▲Mateus Gonçalves▼C. Aquino
   13. 89'
       PAR
       Substitution
       ▲A. Rodríguez▼S. Arzamendia