Club Nacional and Atletico Nacional drew 4-4. Atletico Nacional controlled the ball — 67% possession — but had nothing to show for it. Club Nacional played with ten from minute 42. Gonzalo Bergessio scored 3 goals. Best on the pitch was A. Andrade, rated 9.6.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   URU 3-5-2·4-3-3 COL
   Coach: A. Capuccio · A. GuimarãesReferee: A. Aragón📍 Estadio Gran Parque Central
2. 1. First half
   2. 8'
      COL
      GOOOAL!J. BarreraAssist: J. Duque
   3. 12'
      URU
      GOOOAL!Gonzalo BergessioAssist: L. Fernández
   4. 17'
      URU
      Yellow card
      E. Martinez
   5. 42'
      URU
      Red card
      G. Corujo
   6. 44'
      COL
      Yellow card
      Y. Mosquera
   7. 45+2'
      COL
      GOOOAL!A. Andrade
   8. 45+4'
      URU
      GOOOAL!Leandro FernandezAssist: C. Cándido
3. 1. Second half
   2. 46'
      URU
      Substitution
      ▲Á. Gabrielli▼E. Martinez
   3. 51'
      URU
      GOOOAL!Gonzalo BergessioAssist: C. Cándido
   4. 55'
      COL
      Substitution
      ▲E. Olivera▼Y. Mosquera
   5. 55'
      COL
      Substitution
      ▲Alex Castro▼S. Gomez
   6. 57'
      COL
      Yellow card
      J. Duque
   7. 62'
      URU
      Substitution
      ▲R. Orihuela▼C. Cándido
   8. 64'
      URU
      GOOOAL!Gonzalo BergessioAssist: L. Fernández
   9. 68'
      URU
      Substitution
      ▲G. May▼Leandro Fernandez
   10. 68'
       URU
       Substitution
       ▲G. Vega▼Gonzalo Bergessio
   11. 70'
       COL
       Substitution
       ▲J. Alvez▼Y. Candelo
   12. 71'
       COL
       Yellow card
       Danovis Banguero
   13. 74'
       URU
       Own goalR. Orihuela
   14. 75'
       URU
       Substitution
       ▲M. Cantera▼B. Ocampo
   15. 85'
       COL
       GOOOAL!J. BarreraAssist: A. Andrade
   16. 90+3'
       COL
       Yellow card
       Alex Castro
   17. 90+4'
       URU
       Yellow card
       M. Cantera