River Plate beat Junior 2-1. The winner had to work for it: 2 from 18 shots. Best on the pitch was Julián Álvarez, rated 7.9.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   ARG 3-5-2·4-2-3-1 COL
   Coach: M. Gallardo · L. PereaReferee: J. Benítez📍 Estadio Monumental Antonio Vespucio Liberti
2. 1. First half
   2. 28'
      COL
      Yellow card
      F. Hinestroza
   3. 29'
      ARG
      GOOOAL!H. Martínez
   4. 34'
      ARG
      Yellow card
      G. Montiel
3. 1. Second half
   2. 55'
      ARG
      GOOOAL!Julián ÁlvarezAssist: F. Angileri
   3. 58'
      COL
      Yellow card
      Larry Vásquez
   4. 71'
      ARG
      Substitution
      ▲S. Simon▼A. Palavecino
   5. 71'
      ARG
      Substitution
      ▲Milton Casco▼N. de la Cruz
   6. 71'
      ARG
      Substitution
      ▲Jorge Carrascal▼Julián Álvarez
   7. 71'
      ARG
      Substitution
      ▲Federico Girotti▼R. Borre
   8. 71'
      COL
      Substitution
      ▲Marlon Piedrahita▼F. Viáfara
   9. 71'
      COL
      Substitution
      ▲E. Cetre▼J. Pajoy
   10. 77'
       ARG
       Yellow card
       Milton Casco
   11. 78'
       COL
       Yellow card
       W. Ditta
   12. 83'
       COL
       Substitution
       ▲C. Valencia▼L. González
   13. 90+4'
       COL
       GOOOAL!Miguel Borja