Fluminense beat Santa Fe 1-2. Santa Fe controlled the ball — 73% possession — but had nothing to show for it. The winner had to work for it: 2 from 12 shots. Fluminense played with ten from minute 71. Best on the pitch was Fred, rated 9.2.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   COL 4-2-3-1·4-2-3-1 BRA
   Coach: H. Rivera · Roger MachadoReferee: A. Cunha📍 Estadio Centenario
2. 1. First half
   2. 5'
      BRA
      GOOOAL!FredAssist: Nenê
   3. 37'
      COL
      Yellow card
      Jorge Ramos
3. 1. Second half
   2. 46'
      COL
      Substitution
      ▲Diego Valdes▼Jhon Arias
   3. 46'
      BRA
      GOOOAL!FredAssist: Egídio
   4. 51'
      COL
      GOOOAL!D. GiraldoAssist: J. Palacios
   5. 56'
      BRA
      Yellow card
      Egídio
   6. 61'
      BRA
      Substitution
      ▲J. Cazares▼Nenê
   7. 61'
      BRA
      Substitution
      ▲Gabriel Teixeira▼Kayky
   8. 66'
      COL
      Substitution
      ▲J. Caballero▼Luis Manuel Seijas
   9. 68'
      BRA
      Substitution
      ▲R. Bobadilla▼Fred
   10. 69'
       BRA
       Substitution
       ▲Caio Paulista▼Luiz Henrique
   11. 71'
       BRA
       Yellow card
       Egídio
   12. 71'
       BRA
       Red card
       Egídio
   13. 72'
       BRA
       Substitution
       ▲Danilo Barcelos▼Gabriel Teixeira
   14. 75'
       COL
       Substitution
       ▲J. González▼K. Osorio
   15. 79'
       COL
       Yellow card
       D. Giraldo
   16. 90+3'
       COL
       Substitution
       ▲F. Delgado▼D. Mosquera
   17. 90+5'
       BRA
       Yellow card
       R. Bobadilla