Olimpia beat Always Ready 2-1. The winner had to work for it: 2 from 23 shots. Best on the pitch was Richard Ortiz, rated 7.7.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   PAR 4-3-3·3-5-2 BOL
   Coach: S. Orteman · S. NúñezReferee: N. Lamolina📍 Estadio Manuel Ferreira
2. 1. First half
   2. 9'
      BOL
      Yellow card
      Rodrigo Ramallo
   3. 34'
      BOL
      Yellow card
      H. Cummings
3. 1. Second half
   2. 46'
      PAR
      Substitution
      ▲Roque Santa Cruz▼W. González
   3. 46'
      PAR
      Substitution
      ▲B. Ojeda▼Hugo Quintana
   4. 57'
      BOL
      Substitution
      ▲Edemir Rodriguez▼Vander Vieira
   5. 64'
      PAR
      Own goalDiego Polenta
   6. 68'
      BOL
      Yellow card
      Juan Arce
   7. 68'
      PAR
      Substitution
      ▲Nestor Camacho▼M. Estigarribia
   8. 71'
      PAR
      GOOOAL!Roque Santa Cruz
   9. 74'
      BOL
      Substitution
      ▲J. Mosquera▼M. Ovejero
   10. 74'
       BOL
       Substitution
       ▲C. Arabe▼Juan Arce
   11. 80'
       PAR
       GOOOAL!Richard Ortiz
   12. 81'
       BOL
       Yellow card
       Marc Enoumba
   13. 82'
       BOL
       Substitution
       ▲Samuel Galindo▼Javier Sanguinetti
   14. 82'
       BOL
       Substitution
       ▲C. Algaranaz▼Cristian Machado
   15. 83'
       PAR
       Substitution
       ▲Antolín Alcaraz▼Luis Cáceres
   16. 86'
       PAR
       Yellow card
       J. Recalde
   17. 86'
       PAR
       Substitution
       ▲R. Rojas▼J. Recalde
   18. 87'
       BOL
       Yellow card
       C. Algaranaz
   19. 89'
       PAR
       Yellow card
       A. Benítez