U. Catolica beat Club Nacional 3-1. Club Nacional played with ten from minute 83. Best on the pitch was Clemente Montes, rated 7.3.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   CHI 4-3-3·4-3-1-2 URU
   Coach: G. Poyet · A. CapuccioReferee: Anderson Daronco📍 Estadio San Carlos de Apoquindo
2. 1. First half
   2. 14'
      CHI
      Yellow card
      Raimundo Rebolledo
   3. 30'
      CHI
      GOOOAL!F. ZampedriPenalty
   4. 35'
      CHI
      Yellow card
      J. Leiva
   5. 41'
      URU
      Yellow card
      F. Carballo
   6. 45+1'
      URU
      GOOOAL!Leandro FernandezAssist: F. Carballo
3. 1. Second half
   2. 47'
      CHI
      Yellow card
      I. Saavedra
   3. 58'
      CHI
      Substitution
      ▲Clemente Montes▼Edson Puch
   4. 58'
      CHI
      Substitution
      ▲D. Valencia▼José Pedro Fuenzalida
   5. 59'
      CHI
      GOOOAL!D. Valencia
   6. 62'
      URU
      Substitution
      ▲A. D'Alessandro▼F. Carballo
   7. 70'
      URU
      Substitution
      ▲F. Píriz▼J. Trasante
   8. 77'
      CHI
      Substitution
      ▲L. Aued▼J. Leiva
   9. 82'
      URU
      Substitution
      ▲G. Vega▼B. Ocampo
   10. 83'
       URU
       Red card
       C. Almeida
   11. 85'
       CHI
       Substitution
       ▲T. Asta-Buruaga▼I. Saavedra
   12. 87'
       CHI
       Yellow card
       Juan Cornejo
   13. 90+3'
       CHI
       GOOOAL!Clemente MontesAssist: M. Nuñez