Santa Fe and River Plate drew 0-0. Best on the pitch was Leandro Castellanos, rated 7.6.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   COL 4-1-4-1·4-2-3-1 ARG
   Coach: H. Rivera · M. GallardoReferee: A. Herrera📍 Estadio General Pablo Rojas
2. 1. First half
   2. 12'
      COL
      Yellow card
      Leonardo Pico
   3. 27'
      ARG
      Yellow card
      Bruno Zuculini
3. 1. Second half
   2. 69'
      ARG
      Substitution
      ▲Julián Álvarez▼Benjamín Rollheiser
   3. 74'
      COL
      Substitution
      ▲J. Velásquez▼Enrique Serje
   4. 80'
      ARG
      Substitution
      ▲A. Fontana▼J. Paradela
   5. 85'
      ARG
      Substitution
      ▲A. Palavecino▼Bruno Zuculini