Deportivo Tachira FC beat Internacional 2-1. Internacional controlled the ball — 65% possession — but had nothing to show for it. The winner had to work for it: 2 from 13 shots. Best on the pitch was Thiago Galhardo, rated 7.9.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   VEN 4-1-3-2·4-2-3-1 BRA
   Coach: J. Tolisano · Miguel Ángel RamírezReferee: W. Roldán📍 Estadio Polideportivo de Pueblo Nuevo
2. 1. First half
   2. 22'
      VEN
      Yellow card
      L. Gómez
   3. 26'
      VEN
      Yellow card
      Pablo Camacho
   4. 28'
      BRA
      Yellow card
      Rodrigo Dourado
   5. 44'
      BRA
      Yellow card
      R. Saravia
3. 1. Second half
   2. 51'
      VEN
      Yellow card
      Jose Luis Granados
   3. 52'
      BRA
      GOOOAL!Thiago GalhardoPenalty
   4. 58'
      BRA
      Substitution
      ▲Mauricio▼Marcos Guilherme
   5. 59'
      BRA
      Substitution
      ▲Rodinei▼R. Saravia
   6. 61'
      BRA
      Yellow card
      Thiago Galhardo
   7. 61'
      VEN
      Substitution
      ▲N. Hernández▼E. Pérez Greco
   8. 63'
      VEN
      Yellow card
      M. Covea
   9. 70'
      BRA
      Substitution
      ▲Bruno Praxedes▼Nonato
   10. 70'
       BRA
       Substitution
       ▲Edenílson▼Taison
   11. 73'
       VEN
       Substitution
       ▲Y. Chacón▼F. Góndola
   12. 73'
       VEN
       Substitution
       ▲D. Angarita▼L. Gómez
   13. 77'
       VEN
       GOOOAL!N. Hernández
   14. 80'
       BRA
       Substitution
       ▲Rodrigo Lindoso▼Rodrigo Dourado
   15. 86'
       VEN
       GOOOAL!M. CovaPenalty
   16. 90'
       VEN
       Substitution
       ▲Y. Velasco▼M. Covea
   17. 90+3'
       VEN
       Yellow card
       C. Vivas