The Strongest beat Barcelona SC 2-0. Barcelona SC controlled the ball — 59% possession — but had nothing to show for it. The winner had to work for it: 2 from 12 shots. J. Reinoso scored 2 goals. Best on the pitch was J. Reinoso, rated 8.5.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   BOL 5-3-2·4-2-3-1 ECU
   Coach: L. Orozco · F. BustosReferee: Á. Arteaga📍 Estadio Hernando Siles
2. 1. First half
   2. 1'
      ECU
      Yellow card
      M. Pineida
   3. 10'
      BOL
      Yellow card
      D. Wayar
   4. 22'
      ECU
      Yellow card
      E. Martínez
   5. 44'
      BOL
      Substitution
      ▲Rolando Blackburn▼D. Wayar
   6. 45+1'
      BOL
      GOOOAL!J. Reinoso
3. 1. Second half
   2. 46'
      BOL
      Substitution
      ▲J. Valverde▼David Mateos
   3. 63'
      ECU
      Substitution
      ▲M. Hoyos▼Lupo Quiñónez
   4. 63'
      ECU
      Substitution
      ▲Sergio Lopez▼N. Molina
   5. 65'
      BOL
      GOOOAL!J. ReinosoAssist: R. Blackburn
   6. 69'
      BOL
      Yellow card
      J. Sagredo
   7. 75'
      BOL
      Substitution
      ▲Fran Pastor▼Willie
   8. 76'
      ECU
      Substitution
      ▲Gabriel Cortez▼D. Díaz
   9. 76'
      ECU
      Substitution
      ▲G. Mastriani▼E. Martínez
   10. 76'
       ECU
       Substitution
       ▲J. Perlaza▼Carlos Torres Garcés
   11. 76'
       BOL
       Yellow card
       Rolando Blackburn
   12. 83'
       BOL
       Yellow card
       Fernando Marteli
   13. 90'
       BOL
       Substitution
       ▲M. Zoch▼Fran Pastor
   14. 90+4'
       ECU
       Yellow card
       B. Piñatares